THe following anti-HIV drugs are known to cause 

 

“LIVER TOXICITY”

 

Aptivus

Atripla

Crixivan

Combivir

Emtriva

Epivir

Epzicom

Fortovase

Fuzeon

Hivid

Intelence

Isentress

Kaletra

Lexiva

Norvir

Prezista

Rescriptor

Retrovir

Reyataz

Selzentry

Sustiva

Trizivir

Truvada

Videx

Viramune

Viread

Ziagen

Zerit

 

 

Liver Toxicity causes liver failure Liver failure is now the leading cause of death among HIV patients who ingest HIV drugs.

Clin Infect Dis 32(3):492-497 (2001)

AIDS Res Hum Retroviruses 17(16):1467–1471 (2001)

Amy Justice,14th International AIDS Conference, Barcelona (2002a) (2002b)

 

HIV researchers have NOT identified HIV as a cause for liver toxicity or liver failure. Liver toxicity is exhibited by all classes of anti-HIV drugs.

JAIDS 32(3):259-267 (2003)

 

 

Viramune causes liver toxicity more often than other anti-HIV drugs. Clinically asymptomatic and symptomatic liver toxicity, including rapidly occurring fatal liver failure have been observed. Serious and fatal liver toxicity has been reported even during so-called post-exposure prophylaxis, where HIV-negative people were treated with a short-course of Viramune right after supposed exposure to HIV.

 

 

 

Toxic liver reactions occur at different time points for different drug classes:

 

Fulminant liver failure (acute liver failure) is one of the most challenging gastrointestinal emergencies encountered in clinical practice and encompasses a pattern of clinical symptoms that may lead to the rapid arrest of normal liver function. The syndrome is defined by the sudden onset of hepatic encephalopathy in an otherwise healthy individual. Hepatic encephalopathy is a worsening of brain function that occurs when the liver is no longer able to remove toxic substances in the blood. Patients with hepatic encephalopathy can become unconscious, unresponsive, and possibly enter a coma.


Symptoms of Hepatic Encephalopathy

  • Breath with a musty or sweet odor
  • Change in sleep patterns
  • Changes in thinking
  • Confusion that is mild,
  • Forgetfulness
  • Mental fogginess
  • Personality or mood changes
  • Poor concentration
  • Poor judgment
  • Loss of small hand movements
  • Abnormal movements or shaking of hands or arms
  • Agitation, excitement, or seizures (occur rarely)
  • Disorientation
  • Drowsiness or confusion
  • Inappropriate behavior or severe personality changes
  • Slurred speech
  • Slowed or sluggish movement

 

Hepatic encephalopathy often appears in association with defective blood clotting, jaundice and multi-system organ failure. (See Lactic Acidosis)

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