THe following anti-HIV drugs are known to cause 

 

“Hypersensitivity Reactions”

 

Atripla

Epzicom

Fuzeon

Hivid

Intelence

Rescriptor

Selzentry

Sustiva

Trizivir

Viramune

Ziagen

 


Hypersentitivity refers to excessive, undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system:

 

ch85f6.jpg

 

Hypersensitivity reactions can be divided into four types: type I, type II, type III and type IV, based on the mechanisms involved and time taken for the reaction.

 

Toxic Epidermal Necrolysis

skin.jpg

 

 

The condition may involve more than one of the following reactions:

 

Type I Hypersensitivity can cause the following diseases including cold and stomach flu symptoms within minutes to a few hours of drug use.

 

Urticaria

http://www.pulsetoday.co.uk/pictures/466xAny/n/t/c/urticaria.jpg

 

 

Eczema

http://alsalamdic.files.wordpress.com/2009/07/eczema-arms1.gif

 

Conjunctivitis

 

 

Runny Nose (rhinorrhea)

rhino.jpg

 

 

Asthma

http://wockhardthospitals.files.wordpress.com/2009/08/asthma-britannica.jpg

 

 

Type II Hypersensitivity (cytotoxic hypersensitivity) may cause hemolytic anemia, bone marrow suppression (granulocytopenia), blood platelet suppression (thrombocytopenia),

 

 

 

anemia.jpg

 

Bleeding in the lungs (Goodpasture’s nephritis)

neph.jpg

 

 

Type III Hypersensitivity reactions may involve individual organs including skin (e.g., systemic lupus,  erythematosus, Arthus reaction), kidneys (e.g., lupus nephritis), lungs (e.g., aspergillosis), blood vessels (e.g., polyarteritis), joints (e.g., rheumatoid arthritis) or other organs. This reaction may be the pathogenic mechanism of diseases caused by many microorganisms.

 

LUPUS.jpg

 

Erythematosus

http://www.cfpc.ca/cfp/2007/Mar/_images/vol53-mar-currentpractice-dermacase-gra1.png

 

Erythematous Skin Lesion

http://www.nzma.org.nz/journal/117-1204/1126/CONTENT01.jpg

 

 

Type IV Hypersensitivity is also known as cell mediated or delayed type hypersensitivity. The classical example of this hypersensitivity is tuberculin (Montoux) reaction (figure 5) which peaks 48 hours after the injection of antigen (PPD or old tuberculin). The lesion is characterized by induration and erythema.

 

Tuberculin (Montoux) Reaction

http://www.archbronconeumol.org/ficheros/images/260/260v42n02/grande/260v42n02-13084792fig01.jpg

 

Induration

http://www.savene.com/Multimedia/Day12_S.jpg

 

Erythema

http://meded.ucsd.edu/clinicalimg/skin_erythema_multiforme.jpg

 

warnhyper.jpg

 

 

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